Vassiliki was born Vassiliki Benopoulou on 28 October 1960 in Athens, Greece. She began painting from a young age. Her initial choice of studies was in the School of Greek and English Literature as well as Philosophy in the University of Athens. Subsequently she turned towards art, studying at the College of Arts at the University of La Verne, and then the International School of Art in Umbria under the tutelage of Nicolas Carone. During her studies, Vassiliki was impelled to explore esoteric philosophy and any manifestation of theosophy through the ages.
Parallel to her artistic production, Vassiliki continued research at The School of Fine Art at the University of Leeds taking the Masters program in sculpture and through the support of The Henry Moore Foundation. The subject of her research was the holly symbols in art through the centuries under the supervision of Henry Hughes, rector at the University of Leeds.
Prolific as much in painting as in sculpture, Vassiliki is distinguished for her enormous sculpture installations and environments, as well as her conjectural interventions. Milestones of her art are considered to be such works as Delphic, The Priestesses, Music of Shapes, Vassiliki's Prayer, City of Crosses, Cruciforms, and City of Games.
Vassiliki presented her work in international personal exhibitions. Notably, her seminal exhibition City of Games was shown first at Technopolis of Athens (2000), then at the Place de la Bastille in Paris (2000), and finally in Martiny of Switzerland (2000-2002). Her works are found in public spaces, art institutions, and private collections in Greece and abroad. Vassiliki is a member of The Art Institute of Chicago.